HitPredict

Interactor 1: PCD12 (Q9NPG4)
Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form]
Gene: PCDH12

Interactor 2: PCDGB (Q9Y5H2)
Protocadherin gamma-A11 (PCDH-gamma-A11)
Gene: PCDHGA11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cadherin~Cadherin, Cadherin~Cadherin_2
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1184 Hs			1 935
+	Hs
		1378028 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDG8_HUMAN (4-920): 0: 1035: 73.17
+	Hs
		1378035 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDG4_HUMAN (1-920): 0: 1025: 73.15
+	Hs
		1378034 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDG5_HUMAN (1-920): 0: 1024: 73.80
+	Hs
		1378037 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDG4_HUMAN (1-920): 0: 1025: 73.15
+	Hs
		231362 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDG4_HUMAN (1-920): 0: 1025: 73.15
+	Hs
		1350270 PCD10_HUMAN (18-786): 0: 812: 35.15		PCDGG_HUMAN (27-920): 0: 990: 52.80
+	Hs
		1377978 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDB3_HUMAN (1-778): 0: 969: 44.89
+	Hs
		1342770 PCD12_HUMAN (26-1184): 0: 1280: 100.00		PCDGK_HUMAN (3-457): 2.6e-96: 326: 24.95
+	Hs
		1378014 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDGE_HUMAN (3-445): 7.83e-100: 335: 25.98
+	Hs
		231359 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDGD_HUMAN (3-445): 8.34e-103: 343: 25.33
+	Hs
		1357393 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDGK_HUMAN (3-457): 2.6e-96: 326: 24.95
+	Hs
		231358 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDGE_HUMAN (3-445): 7.83e-100: 335: 25.98
+	Hs
		1378036 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDA9_HUMAN (3-444): 3.64e-90: 309: 25.33
+	Hs
		231363 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDA9_HUMAN (3-444): 3.64e-90: 309: 25.33
+	Hs
		1378030 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDG7_HUMAN (2-348): 8.89e-63: 231: 20.61
+	Hs
		1378031 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDG7_HUMAN (2-348): 8.89e-63: 231: 20.61
+	Hs
		1378023 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDG9_HUMAN (2-375): 5.64e-62: 229: 20.89
+	Hs
		231361 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDG7_HUMAN (2-348): 8.89e-63: 231: 20.61
+	Hs
		231360 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDG9_HUMAN (2-375): 5.64e-62: 229: 20.89