HitPredict

Interactor 1: CCL21 (O00585)
C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21)
Gene: CCL21

Interactor 2: PF4V (P10720)
Platelet factor 4 variant (C-X-C motif chemokine 4 variant) (CXCL4L1) (PF4alt) (PF4var1) [Cleaved into: Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)]
Gene: PF4V1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	28381538
Identification Methods	pull down, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0008009 - chemokine activity GO:0030593 - neutrophil chemotaxis GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 134 Hs			1 104
+	Hs
		134290 CCL21_HUMAN (16-134): 2.31e-36: 122: 100.00		CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89
+	Hs
		134284 CCL21_HUMAN (16-134): 2.31e-36: 122: 100.00		PLF4_HUMAN (12-104): 1.82e-27: 98.2: 89.25
+	Hs
		134283 CCL21_HUMAN (16-134): 2.31e-36: 122: 100.00		CXCL7_HUMAN (41-102): 1.14e-26: 97.1: 54.84
+	Hs
		499207 CCL11_HUMAN (16-99): 4.82e-27: 98.3: 33.33		PF4V_HUMAN (1-104): 3.07e-33: 112: 100.00
+	Hs
		134285 CCL21_HUMAN (16-134): 2.31e-36: 122: 100.00		CXL10_HUMAN (19-101): 3.16e-22: 84.7: 25.88
+	Hs
		364089 CCL13_HUMAN (3-98): 6.52e-31: 107: 30.61		PLF4_HUMAN (12-104): 1.82e-27: 98.2: 89.25
+	Hs
		364057 CCL13_HUMAN (3-98): 6.52e-31: 107: 30.61		CXCL7_HUMAN (41-102): 1.14e-26: 97.1: 54.84
+	Hs
		134298 CCL21_HUMAN (16-134): 2.31e-36: 122: 100.00		CXCL9_HUMAN (34-100): 8.77e-21: 81.6: 26.47
+	Hs
		587776 CCL8_HUMAN (15-99): 3.13e-28: 101: 32.18		CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89
+	Hs
		364047 CCL8_HUMAN (15-99): 3.13e-28: 101: 32.18		CXCL7_HUMAN (41-102): 1.14e-26: 97.1: 54.84
+	Hs
		587775 CCL11_HUMAN (16-99): 4.82e-27: 98.3: 33.33		CXCL2_HUMAN (33-104): 4.01e-28: 99.7: 38.89
+	Hs
		945619 CCL8_HUMAN (15-99): 3.13e-28: 101: 32.18		CXCL6_HUMAN (31-104): 9.33e-27: 96.7: 37.84
+	Hs
		364081 CCL11_HUMAN (16-99): 4.82e-27: 98.3: 33.33		PLF4_HUMAN (12-104): 1.82e-27: 98.2: 89.25
+	Hs
		448992 CCL11_HUMAN (16-99): 4.82e-27: 98.3: 33.33		GROA_HUMAN (38-104): 1.7e-27: 98.2: 43.28
+	Hs
		587789 CCL11_HUMAN (16-99): 4.82e-27: 98.3: 33.33		CXCL3_HUMAN (38-103): 2.66e-26: 95.1: 37.88
+	Hs
		364118 CCL13_HUMAN (3-98): 6.52e-31: 107: 30.61		CXL10_HUMAN (19-101): 3.16e-22: 84.7: 25.88
+	Hs
		486193 CCL8_HUMAN (15-99): 3.13e-28: 101: 32.18		IL8_HUMAN (39-103): 1.76e-23: 87.8: 34.85
+	Hs
		991085 CCL13_HUMAN (3-98): 6.52e-31: 107: 30.61		CXCL9_HUMAN (34-100): 8.77e-21: 81.6: 26.47
+	Hs
		364109 CCL8_HUMAN (15-99): 3.13e-28: 101: 32.18		CXL10_HUMAN (19-101): 3.16e-22: 84.7: 25.88
+	Hs
		364106 CCL11_HUMAN (16-99): 4.82e-27: 98.3: 33.33		CXL10_HUMAN (19-101): 3.16e-22: 84.7: 25.88