HitPredict

Interactor 1: CCL21 (O00585)
C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21)
Gene: CCL21

Interactor 2: CCR7 (P32248)
C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197)
Gene: CCR7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 9507024, 10488147, 22221265
Identification Methods biochemical, experimental interaction detection, competition binding, solution state nmr
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~IL8
Common GO terms GO:0001768 - establishment of T cell polarity
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0002407 - dendritic cell chemotaxis
GO:0002606 - positive regulation of dendritic cell antigen processing and presentation
GO:0006954 - inflammatory response
and 16 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 134
Hs

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Last updated: 15 Jul 2024