HitPredict

Interactor 1: NLRC4 (Q9NPP4)
NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
Gene: NLRC4

Interactor 2: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.931

The method score is based on:

Property Details
Experiments 11374873, 12646168, 14634131, 19337385, 11967258, 24803432
Identification Methods two hybrid, anti tag coimmunoprecipitation, pull down, fluorescence microscopy
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD
Common GO terms GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1024
Hs

1 195
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024