HitPredict

Interactor 1: LHX9 (Q9NQ69)
LIM/homeobox protein Lhx9 (LIM homeobox protein 9)
Gene: LHX9

Interactor 2: ZHX1 (Q9UKY1)
Zinc fingers and homeoboxes protein 1
Gene: ZHX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 397 Hs			1 873
+	Hs
		1354250 LHX3_HUMAN (131-393): 1.86e-35: 136: 18.63		ZHX1_HUMAN (1-873): 0: 847: 100.00
+	Hs
		1281199 LHX4_HUMAN (131-356): 2.18e-32: 127: 20.80		ZHX1_HUMAN (1-873): 0: 847: 100.00
+	Hs
		839773 LHX2_HUMAN (23-397): 7.27e-78: 248: 60.55		ZFHX4_HUMAN (198-722): 3.99e-27: 121: 12.55
+	Hs
		839856 LHX2_HUMAN (23-397): 7.27e-78: 248: 60.55		ZHX2_HUMAN (354-871): 6.12e-19: 94.4: 15.85
+	Hs
		839778 LHX2_HUMAN (23-397): 7.27e-78: 248: 60.55		HOMEZ_HUMAN (654-821): 2.45e-14: 78.7: 29.76
+	Hs
		641346 LHX2_HUMAN (23-397): 7.27e-78: 248: 60.55		PAX6_HUMAN (628-784): 3.52e-12: 71.3: 18.29
+	Hs
		822646 LHX1_HUMAN (71-396): 6.92e-59: 198: 28.83		ZFHX4_HUMAN (198-722): 3.99e-27: 121: 12.55
+	Hs
		839748 LHX2_HUMAN (23-397): 7.27e-78: 248: 60.55		ZFHX3_HUMAN (295-729): 4.4e-11: 69.4: 13.15
+	Hs
		231216 LHX2_HUMAN (23-397): 7.27e-78: 248: 60.55		ZEB2_HUMAN (63-259): 2.75e-09: 63.2: 15.15
+	Hs
		1148497 LHX8_HUMAN (65-397): 2.52e-53: 182: 30.03		LHX6_HUMAN (452-558): 2.69e-14: 77.4: 17.76
+	Hs
		1199935 LHX3_HUMAN (131-393): 1.86e-35: 136: 18.63		ZFHX4_HUMAN (198-722): 3.99e-27: 121: 12.55
+	Ce
		106229 MEC3_CAEEL (64-344): 5.24e-50: 172: 24.47		VAB3_CAEEL (632-774): 1.31e-12: 72.9: 18.79
+	Ce
		104761 LIM7_CAEEL (63-339): 2.34e-47: 169: 26.80		VAB3_CAEEL (632-774): 1.31e-12: 72.9: 18.79
+	Hs
		741104 LHX6_HUMAN (17-383): 9.7e-51: 175: 26.43		ZEB1_HUMAN (18-179): 9.39e-10: 64.8: 18.52
+	Hs
		1354256 LHX3_HUMAN (131-393): 1.86e-35: 136: 18.63		ZHX2_HUMAN (354-871): 6.12e-19: 94.4: 15.85
+	Hs
		1281216 LHX4_HUMAN (131-356): 2.18e-32: 127: 20.80		ZHX2_HUMAN (354-871): 6.12e-19: 94.4: 15.85
+	Hs
		638534 RBTN1_HUMAN (56-191): 8.64e-40: 140: 43.97		HOMEZ_HUMAN (654-821): 2.45e-14: 78.7: 29.76
+	Hs
		1220179 LMO3_HUMAN (71-199): 8.86e-38: 135: 44.28		HOMEZ_HUMAN (654-821): 2.45e-14: 78.7: 29.76
+	Hs
		822689 LHX3_HUMAN (131-393): 1.86e-35: 136: 18.63		LHX1_HUMAN (332-565): 7.88e-13: 73.2: 17.92
+	Hs
		231261 LHX3_HUMAN (131-393): 1.86e-35: 136: 18.63		ZEB2_HUMAN (63-259): 2.75e-09: 63.2: 15.15