HitPredict

Interactor 1: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24255178
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 956 Hs			1 1088
+	Hs
		1343395 CYLD_HUMAN (1-956): 0: 1872: 100.00		ST38L_HUMAN (592-1051): 1.3e-146: 448: 41.30
+	Hs
		1069658 CYLD_HUMAN (1-956): 0: 1872: 100.00		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Hs
		682031 CYLD_HUMAN (1-956): 0: 1872: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		1035211 CYLD_HUMAN (1-956): 0: 1872: 100.00		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		254517 CYLD_HUMAN (1-956): 0: 1872: 100.00		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90