HitPredict

Interactor 1: ACKR2 (O00590)
Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6)
Gene: ACKR2

Interactor 2: CCL4 (P13236)
C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
Gene: CCL4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9405404
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006954 - inflammatory response GO:0006955 - immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 384 Hs			1 92
+	Hs
		526564 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL4_HUMAN (1-92): 8.21e-38: 123: 100.00
+	Hs
		561732 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CL3L1_HUMAN (1-92): 5.95e-38: 123: 58.70
+	Hs
		849619 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56
+	Hs
		849616 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL14_HUMAN (1-92): 2.01e-35: 117: 43.01
+	Hs
		486237 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL3_HUMAN (1-92): 6.04e-35: 116: 57.61
+	Hs
		849614 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL7_HUMAN (17-90): 1.31e-29: 103: 37.33
+	Hs
		528210 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL2_HUMAN (1-90): 1.12e-28: 100: 36.26
+	Hs
		849613 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL18_HUMAN (1-92): 1.1e-28: 100: 43.48
+	Hs
		528252 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL5_HUMAN (1-92): 1.14e-27: 97.7: 45.65
+	Hs
		849617 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL15_HUMAN (1-90): 3.05e-27: 97.3: 37.62
+	Hs
		849504 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL11_HUMAN (1-91): 5.56e-27: 96.2: 40.22
+	Hs
		526561 CXCR5_HUMAN (25-354): 3.22e-88: 272: 31.11		CCL4_HUMAN (1-92): 8.21e-38: 123: 100.00
+	Hs
		118813 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL24_HUMAN (1-90): 1.2e-24: 90.8: 29.67
+	Hs
		849620 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL26_HUMAN (23-90): 2.61e-24: 89.2: 47.06
+	Hs
		486231 CXCR5_HUMAN (25-354): 3.22e-88: 272: 31.11		CCL3_HUMAN (1-92): 6.04e-35: 116: 57.61
+	Mm
		500591 CCR3_MOUSE (33-360): 3.49e-79: 249: 35.44		CCL3_MOUSE (1-92): 5.78e-37: 121: 60.87
+	Hs
		528245 CXCR5_HUMAN (25-354): 3.22e-88: 272: 31.11		CCL5_HUMAN (1-92): 1.14e-27: 97.7: 45.65
+	Hs
		180159 CXCR5_HUMAN (25-354): 3.22e-88: 272: 31.11		CCL16_HUMAN (1-91): 1.41e-23: 88.1: 39.36
+	Mm
		534669 CCR3_MOUSE (33-360): 3.49e-79: 249: 35.44		CCL4_MOUSE (1-92): 2.15e-32: 109: 76.09
+	Hs
		802290 XCR1_HUMAN (11-342): 2.52e-90: 276: 34.94		XCL1_HUMAN (1-91): 1.3e-20: 80.4: 28.57