HitPredict

Interactor 1: DBLOH (Q9NR28)
Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]
Gene: DIABLO

Interactor 2: DBLOH (Q9NR28)
Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]
Gene: DIABLO

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.90	0.863

The method score is based on:

Property	Details
Experiments	10972280, 34247143, 36949045, 36758106, 20957035
Identification Methods	x-ray crystallography, biochemical, pull down, two hybrid, affinity chromatography technology
Interaction Type	association, direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Smac_DIABLO~Smac_DIABLO
Common GO terms	GO:0005739 - mitochondrion GO:0005758 - mitochondrial intermembrane space GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process and 8 others more... GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0008631 - intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008635 - activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0009898 - cytoplasmic side of plasma membrane GO:0035631 - CD40 receptor complex GO:0043065 - positive regulation of apoptotic process GO:0051402 - neuron apoptotic process GO:0097193 - intrinsic apoptotic signaling pathway
Homologous interactions	0

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Last updated: 15 Jul 2024