HitPredict

Interactor 1: SHLB2 (Q9NR46)
Endophilin-B2 (SH3 domain-containing GRB2-like protein B2)
Gene: SH3GLB2

Interactor 2: SHLB2 (Q9NR46)
Endophilin-B2 (SH3 domain-containing GRB2-like protein B2)
Gene: SH3GLB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.798

Property	Details
Experiments	27107012, 20562859
Identification Methods	two hybrid, barcode fusion genetics two hybrid, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	BAR~BAR, SH3_9~SH3_9
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0045296 - cadherin binding and 1 others more... GO:0061024 - membrane organization
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 395 Hs			1 395
+	Hs
		1344263 SHLB2_HUMAN (1-395): 8.6e-89: 275: 100.00		SHLB1_HUMAN (1-395): 2.1e-79: 250: 59.24
+	Hs
		1377531 SHLB1_HUMAN (1-395): 2.1e-79: 250: 59.24		SHLB1_HUMAN (1-395): 2.1e-79: 250: 59.24
+	Hs
		1307446 SH3G3_HUMAN (9-394): 6.12e-74: 235: 21.63		SH3G3_HUMAN (9-394): 6.12e-74: 235: 21.63
+	Hs
		1307430 SH3G3_HUMAN (9-394): 6.12e-74: 235: 21.63		SH3G2_HUMAN (9-394): 9.53e-72: 230: 22.14
+	Hs
		1307429 SH3G2_HUMAN (9-394): 9.53e-72: 230: 22.14		SH3G2_HUMAN (9-394): 9.53e-72: 230: 22.14
+	Mm
		1143920 SH3G2_MOUSE (9-394): 5.37e-71: 228: 22.14		SH3G2_MOUSE (9-394): 5.37e-71: 228: 22.14
+	Hs
		1307415 SH3G3_HUMAN (9-394): 6.12e-74: 235: 21.63		SH3G1_HUMAN (9-394): 8.12e-65: 213: 22.25
+	Hs
		1307414 SH3G2_HUMAN (9-394): 9.53e-72: 230: 22.14		SH3G1_HUMAN (9-394): 8.12e-65: 213: 22.25
+	Hs
		1151009 Q6FGM0_HUMAN (9-394): 8.12e-65: 213: 22.25		Q6FGM0_HUMAN (9-394): 8.12e-65: 213: 22.25
+	Hs
		1307413 SH3G1_HUMAN (9-394): 8.12e-65: 213: 22.25		SH3G1_HUMAN (9-394): 8.12e-65: 213: 22.25
+	Dm
		1249174 Q8SYD9_DROME (2-395): 1.21e-62: 208: 42.17		Q8SYD9_DROME (2-395): 1.21e-62: 208: 42.17
+	Hs
		1148391 SHLB1_HUMAN (1-395): 2.1e-79: 250: 59.24		RHG17_HUMAN (12-361): 1.74e-38: 149: 16.52
+	Hs
		1151011 Q6FGM0_HUMAN (9-394): 8.12e-65: 213: 22.25		Q8IZ09_HUMAN (9-315): 1.46e-41: 149: 22.29
+	Mm
		1143925 SH3G2_MOUSE (9-394): 5.37e-71: 228: 22.14		SH3K1_MOUSE (309-394): 1.09e-12: 71.5: 22.73
+	Hs
		1078900 SH3G2_HUMAN (9-394): 9.53e-72: 230: 22.14		ITSN1_HUMAN (295-395): 2.46e-10: 64.7: 21.78
+	Rn
		192737 SH3G1_RAT (9-394): 5.29e-65: 213: 22.00		SRBS2_RAT (317-394): 2.61e-10: 64.2: 23.75