HitPredict

Interactor 1: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22586326
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016607 - nuclear speck GO:0046872 - metal ion binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 400 Hs			1 2610
+	Hs
		1236567 SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		304360 SIR7_HUMAN (1-400): 0: 535: 100.00		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		1056634 SIR7_HUMAN (1-400): 0: 535: 100.00		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		304246 SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		1347880 SIR5_HUMAN (87-321): 1.97e-68: 220: 20.74		HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40
+	Hs
		1289443 SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94		SMUF2_HUMAN (2235-2607): 4.78e-118: 395: 20.62
+	Hs
		1289446 SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125639 SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		1289425 SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		1056596 SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		983179 SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95