HitPredict

Interactor 1: PYRG2 (Q9NRF8)
CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2)
Gene: CTPS2

Interactor 2: PYRG2 (Q9NRF8)
CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2)
Gene: CTPS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.900

The method score is based on:

Property Details
Experiments 25416956, 16189514, 31515488, 31873303
Identification Methods two hybrid, two hybrid array, 3D electron microscopy, cross-linking study, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CTP_synth_N~CTP_synth_N, CTP_synth_N~GATase, GATase~GATase
Common GO terms GO:0003883 - CTP synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006220 - pyrimidine nucleotide metabolic process
and 5 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 586
Hs

1 586
+ Hs
+ Hs
+ Dm
+ Zm
+ Sc
+ Sc
+ Sc
+ Cj
+ Ec

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024