HitPredict

Interactor 1: I17RB (Q9NRM6)
Interleukin-17 receptor B (IL-17 receptor B) (IL-17RB) (Cytokine receptor-like 4) (IL-17 receptor homolog 1) (IL-17Rh1) (IL17Rh1) (Interleukin-17B receptor) (IL-17B receptor)
Gene: IL17RB

Interactor 2: IL17B (Q9UHF5)
Interleukin-17B (IL-17B) (Cytokine Zcyto7) (Interleukin-20) (IL-20) (Neuronal interleukin-17-related factor)
Gene: IL17B

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.80	0.740

Property	Details
Experiments	10749887, 11058597
Identification Methods	pull down, anti tag coimmunoprecipitation, surface plasmon resonance, fluorescence-activated cell sorting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IL17~IL17R_fnIII_D1, IL17~IL17R_fnIII_D2
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 502 Hs			1 180
+	Hs
		1329156 I17RB_HUMAN (12-502): 0: 734: 100.00		IL25_HUMAN (36-179): 2.2e-27: 102: 23.65
+	Mm
		1257598 I17RB_MOUSE (1-502): 0: 724: 74.55		IL25_MOUSE (92-179): 7.06e-28: 104: 34.78
+	Mm
		1141896 I17RA_MOUSE (14-470): 0: 566: 25.05		IL17C_MOUSE (20-180): 1.98e-50: 162: 25.99
+	Hs
		1083093 I17RA_HUMAN (13-470): 0: 592: 24.50		IL17_HUMAN (96-179): 2.62e-32: 115: 39.29
+	Hs
		1290925 I17RA_HUMAN (13-470): 0: 592: 24.50		IL17F_HUMAN (95-179): 1.19e-31: 113: 36.47
+	Hs
		1290938 I17RA_HUMAN (13-470): 0: 592: 24.50		IL25_HUMAN (36-179): 2.2e-27: 102: 23.65
+	Mm
		1141892 I17RA_MOUSE (14-470): 0: 566: 25.05		IL17F_MOUSE (96-179): 8.05e-31: 111: 38.10
+	Mm
		1141891 I17RA_MOUSE (14-470): 0: 566: 25.05		IL17_MOUSE (80-179): 1.48e-30: 110: 31.00