HitPredict

Interactor 1: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Interactor 2: RASF1 (Q9NS23)
Ras association domain-containing protein 1
Gene: RASSF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	26578655, 28205554
Identification Methods	fluorescent resonance energy transfer, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Pkinase, Nore1-SARAH~Pkinase
Common GO terms	GO:0000922 - spindle pole GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1088 Hs			1 344
+	Hs
		325906 LATS1_HUMAN (1-1083): 0: 734: 49.61		RASF1_HUMAN (1-344): 7.96e-150: 427: 100.00
+	Hs
		682035 AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16		RASF1_HUMAN (1-344): 7.96e-150: 427: 100.00
+	Hs
		983843 STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		682169 AKT2_HUMAN (532-1043): 1.88e-142: 438: 23.64		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		681802 AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		983943 AKT3_HUMAN (532-1043): 3.66e-141: 435: 22.01		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Mm
		682107 AKT1_MOUSE (532-1043): 5.78e-141: 434: 22.16		KPCZ_MOUSE (15-152): 4.36e-33: 131: 24.11
+	Hs
		566359 KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92		KPCA_HUMAN (24-266): 3.82e-36: 140: 12.74
+	Hs
		969095 KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92		GRP3_HUMAN (48-215): 1.37e-34: 135: 20.81
+	Hs
		623873 KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92		KPCL_HUMAN (51-289): 3.04e-34: 134: 17.77
+	Hs
		568728 KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73		GRP3_HUMAN (48-215): 1.37e-34: 135: 20.81
+	Hs
		568636 KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Hs
		610716 KAPCB_HUMAN (638-1022): 1.92e-133: 410: 31.36		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11
+	Mm
		554867 AKT1_MOUSE (532-1043): 5.78e-141: 434: 22.16		KPCE_MOUSE (27-107): 4.01e-13: 72.2: 31.33
+	Hs
		681803 AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16		KPCD_HUMAN (23-114): 2.53e-12: 69.9: 21.74
+	Hs
		969083 KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92		KPCD1_HUMAN (50-183): 2.44e-19: 91: 19.40
+	Hs
		681799 AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16		KPCT_HUMAN (30-114): 9.76e-11: 64.9: 27.06
+	Hs
		969068 KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92		KPCE_HUMAN (27-107): 4.59e-13: 72.2: 31.33
+	Hs
		983951 MRCKB_HUMAN (658-1007): 1.11e-70: 261: 40.34		KPCZ_HUMAN (15-152): 6.03e-34: 133: 24.11