HitPredict

Interactor 1: NRBP2 (Q9NSY0)
Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16)
Gene: NRBP2

Interactor 2: T22D4 (Q9Y3Q8)
TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)
Gene: TSC22D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	25416956, 26186194, 28514442, 33961781, 32707033
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Hs			1 395
+	Hs
		1355633 NRBP_HUMAN (2-500): 1.46e-121: 368: 59.36		T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00
+	Hs
		1330751 WNK1_HUMAN (5-314): 1.72e-107: 354: 29.48		T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00
+	Hs
		1317207 WNK3_HUMAN (29-469): 1.34e-107: 353: 24.62		T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00
+	Hs
		1354609 STK39_HUMAN (34-501): 3.81e-114: 349: 14.78		T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00
+	Hs
		1377724 WNK2_HUMAN (2-314): 1.91e-103: 342: 29.91		T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00
+	Hs
		871507 AAPK2_HUMAN (37-478): 4.84e-109: 336: 15.27		T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00
+	Hs
		1217314 NRBP_HUMAN (2-500): 1.46e-121: 368: 59.36		Q8IV54_HUMAN (1-310): 5.68e-44: 156: 99.68
+	Hs
		1025245 AAPK1_HUMAN (37-476): 4.17e-99: 311: 15.25		T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00
+	Hs
		1077357 NRBP_HUMAN (2-500): 1.46e-121: 368: 59.36		T22D1_HUMAN (28-394): 4.95e-38: 148: 26.81
+	Hs
		1077348 NRBP2_HUMAN (28-501): 4.48e-120: 363: 100.00		T22D1_HUMAN (28-394): 4.95e-38: 148: 26.81
+	Hs
		1077338 WNK1_HUMAN (5-314): 1.72e-107: 354: 29.48		T22D1_HUMAN (28-394): 4.95e-38: 148: 26.81
+	Rn
		914592 AKT3_RAT (10-380): 8.84e-119: 359: 14.17		T22D1_RAT (28-394): 4.07e-36: 142: 27.59
+	Hs
		256836 NRBP_HUMAN (2-500): 1.46e-121: 368: 59.36		T22D2_HUMAN (23-388): 4.37e-28: 118: 27.69
+	Hs
		256831 NRBP2_HUMAN (28-501): 4.48e-120: 363: 100.00		T22D2_HUMAN (23-388): 4.37e-28: 118: 27.69
+	Hs
		1304682 NRBP_HUMAN (2-500): 1.46e-121: 368: 59.36		T22D3_HUMAN (276-395): 2.33e-27: 107: 49.59
+	Hs
		256827 WNK3_HUMAN (29-469): 1.34e-107: 353: 24.62		T22D2_HUMAN (23-388): 4.37e-28: 118: 27.69
+	Hs
		1304681 NRBP2_HUMAN (28-501): 4.48e-120: 363: 100.00		T22D3_HUMAN (276-395): 2.33e-27: 107: 49.59
+	Hs
		256834 STK39_HUMAN (34-501): 3.81e-114: 349: 14.78		T22D2_HUMAN (23-388): 4.37e-28: 118: 27.69
+	Dm
		1098027 NRBP_DROME (13-494): 3.82e-115: 355: 47.31		BUN2_DROME (139-390): 4.04e-11: 66.9: 26.92
+	Hs
		320553 OXSR1_HUMAN (23-501): 1.52e-115: 352: 14.87		TITIN_HUMAN (5-287): 1.18e-10: 65.7: 11.75