HitPredict

Interactor 1: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Interactor 2: PALS2 (Q9NZW5)
Protein PALS2 (MAGUK p55 subfamily member 6) (Membrane protein, palmitoylated 6) (Veli-associated MAGUK 1) (VAM-1)
Gene: PALS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	32296183, 26186194, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	L27~L27, Guanylate_kin~PDZ, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 197 Hs			1 540
+	Hs
		1050418 LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00		MPP2_HUMAN (1-540): 2.39e-179: 519: 66.31
+	Hs
		1050415 LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69		MPP2_HUMAN (1-540): 2.39e-179: 519: 66.31
+	Hs
		159277 LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00		CSKP_HUMAN (1-540): 9.97e-146: 444: 37.92
+	Mm
		251090 LIN7C_MOUSE (1-197): 1.38e-57: 181: 100.00		CSKP_MOUSE (1-540): 1.23e-145: 443: 37.92
+	Hs
		159269 LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69		CSKP_HUMAN (1-540): 9.97e-146: 444: 37.92
+	Mm
		251089 LIN7B_MOUSE (1-196): 4.08e-55: 175: 85.71		CSKP_MOUSE (1-540): 1.23e-145: 443: 37.92
+	Mm
		292498 LIN7C_MOUSE (1-197): 1.38e-57: 181: 100.00		PALS1_MOUSE (1-539): 1.23e-140: 423: 34.05
+	Hs
		1232510 LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00		PALS1_HUMAN (1-539): 7.94e-140: 421: 33.87
+	Hs
		1232501 LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69		PALS1_HUMAN (1-539): 7.94e-140: 421: 33.87
+	Hs
		1132897 LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00		MPP7_HUMAN (1-540): 2.61e-135: 406: 34.74
+	Hs
		1032762 LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00		MPP3_HUMAN (1-539): 7.82e-135: 405: 32.42
+	Hs
		1132892 LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69		MPP7_HUMAN (1-540): 2.61e-135: 406: 34.74
+	Hs
		1032760 LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69		MPP3_HUMAN (1-539): 7.82e-135: 405: 32.42
+	Hs
		91354 LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00		E5RI47_HUMAN (1-196): 6.58e-79: 247: 65.31
+	Hs
		91352 LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69		E5RI47_HUMAN (1-196): 6.58e-79: 247: 65.31
+	Hs
		942387 LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00		DLG4_HUMAN (88-214): 2.24e-14: 78: 16.42
+	Hs
		1021573 LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00		DLG1_HUMAN (7-214): 3.38e-14: 77.6: 14.91
+	Mm
		292491 LIN7C_MOUSE (1-197): 1.38e-57: 181: 100.00		DLG1_MOUSE (30-214): 5.95e-14: 76.8: 14.63
+	Hs
		942382 LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69		DLG4_HUMAN (88-214): 2.24e-14: 78: 16.42
+	Hs
		1021563 LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69		DLG1_HUMAN (7-214): 3.38e-14: 77.6: 14.91