HitPredict

Interactor 1: RPC5 (Q9NVU0)
DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)
Gene: POLR3E

Interactor 2: RPC2 (Q9NW08)
DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B)
Gene: POLR3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	26496610, 28514442, 33961781, 35271311, 24981860, 33674783
Identification Methods	affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RNA_pol_Rpb2_1~RPC5, RNA_pol_Rpb2_5~RPC5
Common GO terms	GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex GO:0005829 - cytosol GO:0045087 - innate immune response GO:0051607 - defense response to virus
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 708 Hs			1 1133
+	Hs
		677027 RPC5_HUMAN (1-708): 0: 1231: 100.00		RPB2_HUMAN (14-1127): 0: 1475: 37.52
+	Hs
		1334513 RPC5_HUMAN (1-708): 0: 1231: 100.00		RPA2_HUMAN (36-1128): 0: 1159: 29.59
+	Sc
		606618 RPC5_YEAST (8-210): 2.28e-56: 195: 22.33		RPC2_YEAST (12-1130): 0: 1471: 62.84