HitPredict

Interactor 1: RPC5 (Q9NVU0)
DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)
Gene: POLR3E

Interactor 2: RPC10 (Q9Y2Y1)
DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11)
Gene: POLR3K

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	33961781, 26496610, 28514442, 24981860, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RNA_POL_M_15KD~RPC5
Common GO terms	GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex GO:0005829 - cytosol GO:0045087 - innate immune response GO:0051607 - defense response to virus
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 708 Hs			1 108
+	Hs
		738895 RPC5_HUMAN (1-708): 0: 1231: 100.00		RPB9_HUMAN (2-108): 1.17e-36: 122: 26.79
+	Hs
		1346858 RPC5_HUMAN (1-708): 0: 1231: 100.00		RPA12_HUMAN (2-108): 2.44e-22: 86: 24.55
+	Sc
		733195 RPC5_YEAST (8-210): 2.28e-56: 195: 22.33		RPC10_YEAST (1-108): 3.54e-31: 107: 50.44