HitPredict

Interactor 1: RN216 (Q9NWF9)
E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)
Gene: RNF216

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	31087003
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 866 Hs			1 147
+	Hs
		849460 RN216_HUMAN (1-866): 0: 1150: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919878 RN216_HUMAN (1-866): 0: 1150: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895928 RN216_HUMAN (1-866): 0: 1150: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		849498 ARI1_HUMAN (426-784): 2.86e-110: 351: 13.94		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		895968 ARI1_HUMAN (426-784): 2.86e-110: 351: 13.94		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1297383 ARI1_HUMAN (426-784): 2.86e-110: 351: 13.94		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		896576 ARI1_HUMAN (426-784): 2.86e-110: 351: 13.94		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		312679 ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		312520 ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		312553 ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		312528 ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		312645 ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		312639 ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Mm
		854557 ARI2_MOUSE (410-784): 6.3e-94: 305: 16.45		UB2E3_MOUSE (4-146): 1.24e-74: 223: 64.34
+	Hs
		312522 ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Mm
		854551 ARI2_MOUSE (410-784): 6.3e-94: 305: 16.45		UB2E1_MOUSE (4-146): 2.56e-73: 219: 64.34
+	Hs
		312529 ARI2_HUMAN (404-784): 5.05e-95: 309: 16.45		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Sc
		549808 HEL1_YEAST (433-784): 1.25e-82: 277: 14.36		UBC4_YEAST (3-147): 9.94e-80: 233: 80.69
+	Dm
		639397 LUBEL_DROME (407-796): 3.7e-71: 258: 14.53		UBCD1_DROME (1-147): 4.66e-82: 239: 92.52
+	Mm
		895978 RNF31_MOUSE (464-796): 7.86e-66: 240: 15.64		UB2D3_MOUSE (1-147): 1.56e-81: 238: 91.84