HitPredict

Interactor 1: BCD1 (Q9NWK9)
Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6)
Gene: ZNHIT6

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	25404746, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TIP49~zf-HIT
Common GO terms	GO:0000492 - box C/D snoRNP assembly GO:0001094 - TFIID-class transcription factor complex binding GO:0005634 - nucleus GO:0051117 - ATPase binding GO:0070062 - extracellular exosome
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 470 Hs			1 456
+	Mm
		888057 BCD1_MOUSE (1-470): 0: 616: 70.83		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		1347221 BCD1_HUMAN (1-470): 0: 631: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		754089 BCD1_YEAST (219-457): 7.4e-72: 233: 21.60		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		754094 BCD1_YEAST (219-457): 7.4e-72: 233: 21.60		RUVB2_YEAST (5-455): 0: 627: 41.72