HitPredict

Interactor 1: CCL22 (O00626)
C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]
Gene: CCL22

Interactor 2: DPP4 (P27487)
Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]
Gene: DPP4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	9933589, 21314817
Identification Methods	enzymatic study, chromatography technology, protease assay
Interaction Type	direct interaction, protein cleavage, cleavage reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 93 Hs			1 766
+	Hs
		528241 CCL5_HUMAN (16-92): 1.1e-25: 92.7: 29.87		DPP4_HUMAN (1-766): 0: 862: 100.00
+	Hs
		648690 CCL11_HUMAN (22-93): 1.1e-24: 90.4: 30.14		DPP4_HUMAN (1-766): 0: 862: 100.00
+	Hs
		134741 CCL22_HUMAN (24-93): 1.18e-23: 87.7: 100.00		DPP8_HUMAN (79-764): 1.63e-169: 513: 22.21