HitPredict

Interactor 1: CCL22 (O00626)
C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]
Gene: CCL22

Interactor 2: CCR7 (P32248)
C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197)
Gene: CCR7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15546958
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006954 - inflammatory response GO:0006955 - immune response GO:0007186 - G protein-coupled receptor signaling pathway GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 93 Hs			1 378
+	Hs
		561732 CL3L1_HUMAN (3-92): 1.08e-32: 110: 28.89		CCR3_HUMAN (27-366): 4.39e-86: 266: 34.50
+	Hs
		526564 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		CCR3_HUMAN (27-366): 4.39e-86: 266: 34.50
+	Hs
		486237 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CCR3_HUMAN (27-366): 4.39e-86: 266: 34.50
+	Mm
		500591 CCL3_MOUSE (3-92): 5.84e-31: 106: 31.11		CCR3_MOUSE (21-377): 1.63e-75: 239: 31.48
+	Hs
		561728 CL3L1_HUMAN (3-92): 1.08e-32: 110: 28.89		CCR1_HUMAN (44-371): 1.58e-72: 231: 35.76
+	Hs
		486238 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CCR4_HUMAN (23-374): 7.17e-73: 232: 34.71
+	Hs
		526560 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		CCR1_HUMAN (44-371): 1.58e-72: 231: 35.76
+	Hs
		486230 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CCR1_HUMAN (44-371): 1.58e-72: 231: 35.76
+	Hs
		783833 CCL13_HUMAN (3-93): 1.09e-30: 105: 29.67		CCR2_HUMAN (28-359): 4.77e-72: 230: 35.44
+	Mm
		486358 CCL2_MOUSE (3-93): 5.06e-30: 105: 27.17		CCR2_MOUSE (33-367): 1.39e-70: 227: 33.04
+	Hs
		526561 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		CXCR5_HUMAN (55-376): 1.39e-69: 224: 35.47
+	Hs
		561733 CL3L1_HUMAN (3-92): 1.08e-32: 110: 28.89		CCR5_HUMAN (31-374): 1.22e-68: 221: 34.19
+	Hs
		486231 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CXCR5_HUMAN (55-376): 1.39e-69: 224: 35.47
+	Hs
		526565 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		CCR5_HUMAN (31-374): 1.22e-68: 221: 34.19
+	Hs
		486239 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CCR5_HUMAN (31-374): 1.22e-68: 221: 34.19
+	Mm
		500590 CCL3_MOUSE (3-92): 5.84e-31: 106: 31.11		CCR1_MOUSE (27-371): 9.96e-66: 214: 32.76
+	Hs
		134356 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		ACKR2_HUMAN (47-337): 9.63e-42: 152: 35.71
+	Hs
		134354 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		ACKR2_HUMAN (47-337): 9.63e-42: 152: 35.71
+	Hs
		134400 CCL13_HUMAN (3-93): 1.09e-30: 105: 29.67		ACKR2_HUMAN (47-337): 9.63e-42: 152: 35.71
+	Mm
		139696 CCL2_MOUSE (3-93): 5.06e-30: 105: 27.17		ACKR2_MOUSE (31-337): 3.29e-39: 145: 33.44