HitPredict

Interactor 1: SAP18 (O00422)
Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)
Gene: SAP18

Interactor 2: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

The method score is based on:

Property	Details
Experiments	22388736, 33961781, 16537548, 12665594, unassigned3799, 39522233
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	RRM_1~SAP18
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 5 others more... GO:0008380 - RNA splicing GO:0016607 - nuclear speck GO:0043065 - positive regulation of apoptotic process GO:0048025 - negative regulation of mRNA splicing, via spliceosome GO:0061574 - ASAP complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	153
Hs

1	305

Service provided by Combinatics, Japan

Last updated: 11Aug2025