Interactor 1: IRAK4 (Q9NWZ3)
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)
Gene: IRAK4

Interactor 2: IRAK4 (Q9NWZ3)
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)
Gene: IRAK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.845

The method score is based on:

Property Details
Experiments 17141195, 21220427, 24316379
Identification Methods in-gel kinase assay, protein kinase assay, molecular sieving
Interaction Type phosphorylation reaction, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0000287 - magnesium ion binding
GO:0002224 - toll-like receptor signaling pathway
GO:0002446 - neutrophil mediated immunity
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity
and 27 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 460
Hs

1 460
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Last updated: 15 Jul 2024