HitPredict

Interactor 1: TAB2 (Q9NYJ8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
Gene: TAB2

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.661

The method score is based on:

Property	Details
Experiments	23986494, 17626013, 21988832
Identification Methods	pull down, affinity chromatography technology, two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006954 - inflammatory response GO:0042742 - defense response to bacterium and 2 others more... GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0070530 - K63-linked polyubiquitin modification-dependent protein binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	693
Hs

1	419

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024