HitPredict

Interactor 1: IMA3 (O00629)
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)
Gene: KPNA4

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	35271311, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~Ras, Arm_3~Ras
Common GO terms	GO:0005634 - nucleus GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 521 Hs			1 216
+	Hs
		131414 IMA4_HUMAN (1-521): 2.77e-161: 469: 85.80		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		853230 IMA1_HUMAN (1-521): 1.39e-145: 430: 49.62		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698915 IMA1_YEAST (2-521): 1.2e-140: 417: 44.90		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Hs
		853561 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		168627 IMA6_HUMAN (1-521): 7.28e-137: 408: 46.75		RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13