HitPredict

Interactor 1: IMA3 (O00629)
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)
Gene: KPNA4

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0010467 - gene expression
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 521 Hs			1 768
+	Hs
		131433 IMA4_HUMAN (1-521): 2.77e-161: 469: 85.80		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		853273 IMA1_HUMAN (1-521): 1.39e-145: 430: 49.62		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		238673 IMA7_HUMAN (1-521): 3.56e-142: 421: 46.46		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		168634 IMA6_HUMAN (1-521): 7.28e-137: 408: 46.75		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		853593 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		134894 IMA3_HUMAN (1-521): 1.57e-165: 480: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		131434 IMA4_HUMAN (1-521): 2.77e-161: 469: 85.80		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		134895 IMA3_HUMAN (1-521): 1.57e-165: 480: 100.00		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		853274 IMA1_HUMAN (1-521): 1.39e-145: 430: 49.62		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		853594 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		853595 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		853272 IMA1_HUMAN (1-521): 1.39e-145: 430: 49.62		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		853592 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		CUL1_HUMAN (18-768): 0: 707: 30.57