HitPredict

Interactor 1: IF2B1 (Q9NZI8)
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)
Gene: IGF2BP1

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29395067, 17932509
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 859
+	Mm
		291672 IF2B1_MOUSE (1-577): 3.04e-147: 438: 99.31		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Mm
		1208652 IF2B3_MOUSE (1-577): 1.93e-145: 434: 71.50		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Hs
		128336 IF2B3_HUMAN (1-577): 4.61e-149: 443: 71.85		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1349167 IF2B1_HUMAN (1-577): 4.69e-147: 437: 100.00		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1336278 IF2B1_HUMAN (1-577): 4.69e-147: 437: 100.00		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		1072205 PCBP2_HUMAN (407-575): 6.35e-44: 162: 27.43		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1072207 PCBP2_HUMAN (407-575): 6.35e-44: 162: 27.43		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Ce
		108534 Q21605_CAEEL (195-576): 3.09e-62: 221: 26.22		G5EGR6_CAEEL (19-859): 0: 1102: 67.09
+	Mm
		1130844 IF2B2_MOUSE (79-477): 6.06e-20: 95.4: 14.57		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Hs
		1356637 IF2B2_HUMAN (79-477): 2.19e-19: 93.9: 14.84		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1294275 FUBP3_HUMAN (190-413): 5.36e-18: 89.3: 18.25		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1356726 IF2B2_HUMAN (79-477): 2.19e-19: 93.9: 14.84		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1294277 FUBP3_HUMAN (190-413): 5.36e-18: 89.3: 18.25		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1294256 FUBP3_HUMAN (190-413): 5.36e-18: 89.3: 18.25		AGO3_HUMAN (5-859): 0: 1165: 79.75