HitPredict

Interactor 1: PD1L1 (Q9NZQ7)
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Gene: CD274

Interactor 2: TNPO3 (Q9Y5L0)
Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)
Gene: TNPO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.50	0.633

Property	Details
Experiments	26186194, 28514442, 32941674, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 290 Hs			1 923
+	Hs
		1166581 BTNL9_HUMAN (14-289): 1.23e-48: 171: 14.44		TNPO3_HUMAN (1-923): 0: 657: 100.00
+	Hs
		1294601 VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11		TNPO3_HUMAN (1-923): 0: 657: 100.00
+	Hs
		163394 PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Hs
		163148 VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Hs
		312409 PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00		IPO7_HUMAN (13-813): 8.63e-101: 340: 11.63
+	Hs
		208015 PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00		XPOT_HUMAN (12-770): 1.76e-93: 318: 15.10
+	Hs
		1273232 PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00		TNPO1_HUMAN (66-784): 4e-93: 316: 12.71
+	Hs
		155653 PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00		TNPO2_HUMAN (68-784): 3.33e-92: 313: 12.26
+	Hs
		312303 BTNL9_HUMAN (14-289): 1.23e-48: 171: 14.44		IPO7_HUMAN (13-813): 8.63e-101: 340: 11.63
+	Hs
		178283 PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00		IPO8_HUMAN (10-813): 5.2e-89: 307: 9.92
+	Hs
		127391 PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00		IPO5_HUMAN (68-703): 1.92e-86: 301: 13.24
+	Hs
		1166522 BTNL9_HUMAN (14-289): 1.23e-48: 171: 14.44		TNPO1_HUMAN (66-784): 4e-93: 316: 12.71
+	Hs
		155590 BTNL9_HUMAN (14-289): 1.23e-48: 171: 14.44		TNPO2_HUMAN (68-784): 3.33e-92: 313: 12.26
+	Hs
		312358 VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11		IPO7_HUMAN (13-813): 8.63e-101: 340: 11.63
+	Hs
		178195 BTNL9_HUMAN (14-289): 1.23e-48: 171: 14.44		IPO8_HUMAN (10-813): 5.2e-89: 307: 9.92
+	Hs
		1273203 VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11		TNPO1_HUMAN (66-784): 4e-93: 316: 12.71
+	Hs
		155624 VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11		TNPO2_HUMAN (68-784): 3.33e-92: 313: 12.26
+	Hs
		1117742 PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00		Q4LE60_HUMAN (161-691): 3.09e-11: 69.5: 9.70
+	Hs
		1294594 VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11		XPO5_HUMAN (9-614): 3.04e-22: 105: 14.21
+	Hs
		1117739 VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11		Q4LE60_HUMAN (161-691): 3.09e-11: 69.5: 9.70