HitPredict

Interactor 1: KCND2 (Q9NZV8)
Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)
Gene: KCND2

Interactor 2: CSEN (Q9Y2W7)
Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)
Gene: KCNIP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32641494, 23692269
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BTB_2~EF-hand_8, EF-hand_7~Ion_trans, EF-hand_7~Shal-type, EF-hand_8~Shal-type
Common GO terms	GO:0005886 - plasma membrane GO:0008076 - voltage-gated potassium channel complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 630 Hs			1 256
+	Rn
		1144387 KCND2_RAT (1-630): 0: 626: 99.05		KCIP1_RAT (61-256): 5.55e-70: 216: 68.88
+	Hs
		1349118 KCND2_HUMAN (1-630): 0: 625: 100.00		KCIP1_HUMAN (61-256): 3.63e-70: 216: 69.90
+	Hs
		906793 KCND2_HUMAN (1-630): 0: 625: 100.00		NCS1_HUMAN (67-256): 1.71e-66: 206: 42.63
+	Rn
		1144388 KCND2_RAT (1-630): 0: 626: 99.05		KCIP2_RAT (2-256): 7.44e-60: 192: 58.58
+	Hs
		1345312 KCND2_HUMAN (1-630): 0: 625: 100.00		KCIP2_HUMAN (2-256): 1.48e-60: 193: 60.30
+	Mm
		1337485 KCND2_MOUSE (1-630): 0: 625: 99.05		KCIP2_MOUSE (2-256): 4.52e-60: 192: 58.58
+	Hs
		1349120 KCND3_HUMAN (1-626): 0: 572: 73.99		KCIP1_HUMAN (61-256): 3.63e-70: 216: 69.90
+	Hs
		1345313 KCND3_HUMAN (1-626): 0: 572: 73.99		KCIP2_HUMAN (2-256): 1.48e-60: 193: 60.30
+	Ce
		108347 Q95XD1_CAEEL (3-576): 3.17e-163: 481: 56.55		G5EGM2_CAEEL (75-250): 2.38e-62: 196: 36.36
+	Dm
		572848 KCNAL_DROME (3-539): 5.72e-164: 482: 68.09		Q9VBL2_DROME (52-254): 1.21e-60: 192: 48.04