HitPredict

Interactor 1: CXXC1 (Q9P0U4)
CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)
Gene: CXXC1

Interactor 2: SET1B (Q9UPS6)
Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)
Gene: SETD1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	26496610, 27563068, 24981860, 17355966, 23870121, 28514442, 33961781, 23508102, 19433449, 18680430
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 1966
+	Hs
		1349847 CXXC1_HUMAN (1-656): 0: 739: 100.00		KMT2B_HUMAN (1069-1966): 4.68e-71: 268: 21.69
+	Hs
		975335 CXXC1_HUMAN (1-656): 0: 739: 100.00		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Hs
		1243846 CXXC1_HUMAN (1-656): 0: 739: 100.00		KMT2C_HUMAN (1759-1966): 1.32e-58: 227: 37.04
+	Hs
		165726 CXXC1_HUMAN (1-656): 0: 739: 100.00		SET1A_HUMAN (409-1966): 1e-54: 214: 22.13
+	Hs
		152694 CXXC1_HUMAN (1-656): 0: 739: 100.00		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85
+	Hs
		1357294 KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96		SET1B_HUMAN (1-1966): 3.57e-162: 549: 100.00
+	Hs
		975350 KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79		SET1B_HUMAN (1-1966): 3.57e-162: 549: 100.00
+	Hs
		203807 MBD1_HUMAN (27-356): 1.72e-46: 175: 21.56		SUV91_HUMAN (1686-1965): 2.95e-70: 244: 17.93
+	Hs
		975346 KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Hs
		975225 KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Hs
		1243852 KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96		KMT2C_HUMAN (1759-1966): 1.32e-58: 227: 37.04
+	Dm
		1129089 CXXC1_DROME (5-354): 1.44e-48: 182: 21.85		SET1_DROME (30-197): 5.94e-53: 208: 38.60
+	Hs
		975264 KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79		EZH2_HUMAN (1464-1949): 9.8e-64: 235: 15.84
+	Hs
		165737 KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96		SET1A_HUMAN (409-1966): 1e-54: 214: 22.13
+	Hs
		975285 KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79		KMT2C_HUMAN (1759-1966): 1.32e-58: 227: 37.04
+	Hs
		165665 KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79		SET1A_HUMAN (409-1966): 1e-54: 214: 22.13
+	Hs
		331907 KDM2A_HUMAN (95-344): 1.63e-29: 127: 18.27		NSD2_HUMAN (1654-1965): 6.33e-60: 230: 22.15
+	Hs
		152700 KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85
+	Hs
		152630 KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85