Interactor 1: HCN3 (Q9P1Z3)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Gene: HCN3

Interactor 2: HCN4 (Q9Y3Q4)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene: HCN4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 12928435, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, Ion_trans~cNMP_binding, Ion_trans_N~cNMP_binding, Ion_trans~Ion_trans, Ion_trans~Ion_trans_N
Common GO terms GO:0003254 - regulation of membrane depolarization
GO:0005248 - voltage-gated sodium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005886 - plasma membrane
GO:0030424 - axon
and 6 others

more...

Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 774
Hs

1 1203
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Last updated: 15 Jul 2024