HitPredict

Interactor 1: KLH42 (Q9P2K6)
Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)
Gene: KLHL42

Interactor 2: KLDC2 (Q9Y2U9)
Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)
Gene: KLHDC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Kelch_1~Kelch_4
Common GO terms	GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 406
+	Hs
		1121285 KLH22_HUMAN (6-501): 8.93e-110: 341: 19.21		KLH20_HUMAN (165-406): 2.16e-53: 189: 13.17
+	Hs
		1377320 KLH20_HUMAN (4-499): 2.21e-108: 336: 18.99		KLH20_HUMAN (165-406): 2.16e-53: 189: 13.17
+	Hs
		1121287 KLH22_HUMAN (6-501): 8.93e-110: 341: 19.21		IPP_HUMAN (5-276): 1.07e-46: 170: 13.98
+	Hs
		1348053 KLH13_HUMAN (2-505): 5.44e-102: 321: 18.56		KLH28_HUMAN (87-404): 1.39e-52: 186: 13.85
+	Hs
		1348052 KLHL9_HUMAN (2-504): 4.12e-102: 320: 17.34		KLH28_HUMAN (87-404): 1.39e-52: 186: 13.85
+	Hs
		1377325 KLH20_HUMAN (4-499): 2.21e-108: 336: 18.99		IPP_HUMAN (5-276): 1.07e-46: 170: 13.98
+	Hs
		1350373 KLHL9_HUMAN (2-504): 4.12e-102: 320: 17.34		IPP_HUMAN (5-276): 1.07e-46: 170: 13.98
+	Hs
		1049352 KEAP1_HUMAN (4-504): 6.64e-101: 317: 15.75		KLHL3_HUMAN (165-400): 3.41e-45: 166: 14.41
+	Hs
		1377330 KLH20_HUMAN (4-499): 2.21e-108: 336: 18.99		NS1BP_HUMAN (122-404): 4.29e-37: 144: 11.01
+	Hs
		1120830 KLH20_HUMAN (4-499): 2.21e-108: 336: 18.99		KLH12_HUMAN (6-156): 1.27e-25: 110: 16.56
+	Hs
		1049204 KEAP1_HUMAN (4-504): 6.64e-101: 317: 15.75		KEAP1_HUMAN (226-406): 5.71e-30: 123: 15.76
+	Mm
		1378292 KEAP1_MOUSE (4-504): 1.96e-99: 314: 16.46		KEAP1_MOUSE (226-406): 3.36e-29: 121: 15.22
+	Hs
		1120822 KLH13_HUMAN (2-505): 5.44e-102: 321: 18.56		KLH12_HUMAN (6-156): 1.27e-25: 110: 16.56
+	Hs
		1120821 KLHL9_HUMAN (2-504): 4.12e-102: 320: 17.34		KLH12_HUMAN (6-156): 1.27e-25: 110: 16.56
+	Hs
		1049221 KEAP1_HUMAN (4-504): 6.64e-101: 317: 15.75		KLH12_HUMAN (6-156): 1.27e-25: 110: 16.56
+	Hs
		1121277 KLH22_HUMAN (6-501): 8.93e-110: 341: 19.21		KLHL9_HUMAN (265-402): 2.48e-13: 73.6: 15.07
+	Hs
		1121278 KLH22_HUMAN (6-501): 8.93e-110: 341: 19.21		KLH13_HUMAN (280-402): 3.05e-13: 73.2: 13.74
+	Hs
		1350368 KLH13_HUMAN (2-505): 5.44e-102: 321: 18.56		KLHL9_HUMAN (265-402): 2.48e-13: 73.6: 15.07
+	Hs
		1350479 KLH13_HUMAN (2-505): 5.44e-102: 321: 18.56		KLH13_HUMAN (280-402): 3.05e-13: 73.2: 13.74