HitPredict

Interactor 1: NFIB (O00712)
Nuclear factor 1 B-type (NF1-B) (Nuclear factor 1/B) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/B) (NF-I/B) (NFI-B) (TGGCA-binding protein)
Gene: NFIB

Interactor 2: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 420 Hs			1 5537
+	Hs
		152648 NFIX_HUMAN (2-414): 0: 614: 61.70		KMT2D_HUMAN (1-5537): 0: 1986: 100.00
+	Hs
		152576 NFIC_HUMAN (1-412): 0: 603: 64.86		KMT2D_HUMAN (1-5537): 0: 1986: 100.00
+	Hs
		152636 NFIA_HUMAN (2-414): 0: 573: 63.12		KMT2D_HUMAN (1-5537): 0: 1986: 100.00
+	Hs
		135163 NFIB_HUMAN (1-420): 0: 702: 100.00		EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17
+	Hs
		1060369 NFIX_HUMAN (2-414): 0: 614: 61.70		EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17
+	Hs
		1060355 NFIX_HUMAN (2-414): 0: 614: 61.70		EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77
+	Hs
		443252 NFIC_HUMAN (1-412): 0: 603: 64.86		EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17
+	Hs
		443233 NFIC_HUMAN (1-412): 0: 603: 64.86		EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77
+	Hs
		1018269 NFIA_HUMAN (2-414): 0: 573: 63.12		EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17
+	Hs
		135142 NFIB_HUMAN (1-420): 0: 702: 100.00		DPF1_HUMAN (240-320): 4.65e-15: 82.8: 46.43
+	Hs
		135133 NFIB_HUMAN (1-420): 0: 702: 100.00		KMT2C_HUMAN (223-338): 3.09e-09: 66.3: 40.34
+	Hs
		975253 NFIX_HUMAN (2-414): 0: 614: 61.70		KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24
+	Hs
		1060388 NFIX_HUMAN (2-414): 0: 614: 61.70		KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31
+	Hs
		165678 NFIX_HUMAN (2-414): 0: 614: 61.70		SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15
+	Hs
		443242 NFIC_HUMAN (1-412): 0: 603: 64.86		NSD3_HUMAN (175-329): 6.17e-23: 111: 17.79
+	Hs
		1060341 NFIX_HUMAN (2-414): 0: 614: 61.70		DPF1_HUMAN (240-320): 4.65e-15: 82.8: 46.43
+	Hs
		1060330 NFIX_HUMAN (2-414): 0: 614: 61.70		KMT2C_HUMAN (223-338): 3.09e-09: 66.3: 40.34
+	Hs
		1018247 NFIA_HUMAN (2-414): 0: 573: 63.12		DPF1_HUMAN (240-320): 4.65e-15: 82.8: 46.43