HitPredict

Interactor 1: POF10 (Q9P7W4)
F-box/WD repeat-containing protein pof10 (Skp1-binding protein 2)
Gene: POF10

Interactor 2: SKP1 (Q9Y709)
Suppressor of kinetochore protein 1 (P19/Skp1 homolog)
Gene: SKP1

Species: Schizosaccharomyces pombe 972h-

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.908

Property	Details
Experiments	11820777, 15147268, 17016471, 19748355
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 662 Sp			1 161
+	Hs
		929116 FBXW2_HUMAN (7-309): 4.29e-60: 210: 21.22		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Mm
		1351515 Q9QUH1_MOUSE (7-309): 5.53e-59: 206: 21.22		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Sp
		953229 POF1_SCHPO (30-296): 3.56e-39: 154: 16.77		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Mm
		1257397 FBXW7_MOUSE (251-556): 2.56e-33: 138: 11.54		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Hs
		929021 FBXW7_HUMAN (251-556): 8.42e-33: 136: 11.54		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Sp
		1000009 POF11_SCHPO (102-293): 3.98e-21: 99.1: 16.08		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Sp
		144900 POP2_SCHPO (75-274): 3.16e-20: 97.1: 18.41		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Dm
		285012 Q9VDE3_DROME (202-510): 7.06e-23: 104: 12.10		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Sp
		953235 POP1_SCHPO (107-276): 8.08e-18: 89.8: 13.87		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Dm
		1180601 Q9VDE3_DROME (202-510): 7.06e-23: 104: 12.10		Q7KJ69_DROME (1-161): 4.35e-74: 220: 53.37
+	Hs
		929125 FBW1A_HUMAN (330-507): 9.23e-16: 82.8: 11.05		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Mm
		1112932 FBW1A_MOUSE (330-507): 4.35e-15: 80.9: 10.50		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Xl
		1174984 TRCB_XENLA (363-507): 3.87e-15: 80.5: 10.35		SKP1_XENLA (1-161): 9e-82: 240: 55.76
+	Hs
		929110 FBW1B_HUMAN (330-507): 4.49e-15: 80.5: 12.71		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Mm
		1131317 FBW1B_MOUSE (363-507): 8.01e-15: 79.7: 11.03		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Dm
		218244 O44382_DROME (361-518): 7.01e-16: 82.8: 8.86		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Dm
		285042 FBXW7_DROME (411-546): 1.18e-14: 80.1: 12.50		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Dm
		1363661 Q9VDE3_DROME (202-510): 7.06e-23: 104: 12.10		Q9VWC4_DROME (2-151): 2.3e-65: 198: 47.71
+	Sc
		759309 MET30_YEAST (397-594): 1.97e-17: 88.2: 12.13		SKP1_YEAST (2-161): 5.56e-66: 201: 50.00
+	Ce
		105997 LIN23_CAEEL (103-252): 1.52e-12: 72.9: 20.92		G5EDD8_CAEEL (3-160): 3.13e-67: 203: 46.34