HitPredict

Interactor 1: Q9QUH1 (Q9QUH1)
F-box and WD-40 domain protein 2 (F-box protein FWD2)
Gene: Fbxw2

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	10585767, 11735228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Mm			1 163
+	Hs
		929116 FBXW2_HUMAN (1-453): 1.5e-101: 312: 98.68		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Ce
		105997 LIN23_CAEEL (5-450): 3.1e-79: 260: 18.24		G5EDD8_CAEEL (4-162): 4.74e-67: 203: 60.25
+	Sc
		431143 CDC4_YEAST (11-417): 2.48e-75: 252: 17.41		SKP1_YEAST (4-163): 2.12e-66: 202: 42.63
+	Mm
		1257397 FBXW7_MOUSE (30-300): 5.79e-53: 190: 18.09		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Hs
		929021 FBXW7_HUMAN (30-264): 1.59e-52: 189: 19.92		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		929125 FBW1A_HUMAN (214-451): 3.4e-40: 153: 16.46		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Mm
		1112932 FBW1A_MOUSE (214-451): 1.95e-39: 151: 16.87		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Xl
		1174984 TRCB_XENLA (214-451): 1.65e-39: 150: 16.05		SKP1_XENLA (1-163): 5.9e-91: 263: 99.39
+	Ce
		105479 SEL10_CAEEL (78-346): 3.37e-48: 175: 18.48		SKR1_CAEEL (4-162): 1.3e-80: 237: 70.81
+	Mm
		1131317 FBW1B_MOUSE (214-451): 3.15e-38: 147: 17.70		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Hs
		929110 FBW1B_HUMAN (214-451): 3.27e-38: 147: 16.87		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Hs
		245588 TBL1X_HUMAN (220-454): 1e-37: 146: 14.04		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Dm
		218244 O44382_DROME (223-451): 2.44e-39: 150: 15.81		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Dm
		285012 Q9VDE3_DROME (223-451): 3.94e-39: 149: 15.39		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Dm
		1180601 Q9VDE3_DROME (223-451): 3.94e-39: 149: 15.39		Q7KJ69_DROME (1-163): 1.72e-76: 226: 67.49
+	Dm
		1363661 Q9VDE3_DROME (223-451): 3.94e-39: 149: 15.39		Q9VWC4_DROME (2-153): 2.29e-65: 198: 56.86
+	Sp
		1000009 POF11_SCHPO (78-309): 7.51e-30: 123: 21.01		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36
+	Dm
		285042 FBXW7_DROME (310-452): 1.24e-22: 103: 11.72		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Sp
		953235 POP1_SCHPO (116-291): 1.27e-25: 111: 16.48		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36
+	Sc
		759309 MET30_YEAST (307-448): 2.84e-17: 86.4: 11.11		SKP1_YEAST (4-163): 2.12e-66: 202: 42.63