HitPredict

Interactor 1: Q9QUH1 (Q9QUH1)
F-box and WD-40 domain protein 2 (F-box protein FWD2)
Gene: Fbxw2

Interactor 2: CUL1 (Q9WTX6)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	10585767, 11735228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Mm			1 776
+	Hs
		1041272 FBXW2_HUMAN (1-453): 1.5e-101: 312: 98.68		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Mm
		1257398 FBXW7_MOUSE (30-300): 5.79e-53: 190: 18.09		CUL1_MOUSE (1-776): 0: 912: 100.00
+	Hs
		1041133 FBXW7_HUMAN (30-264): 1.59e-52: 189: 19.92		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		903206 WDR5_HUMAN (32-253): 6.76e-43: 155: 15.19		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1041292 FBW1A_HUMAN (214-451): 3.4e-40: 153: 16.46		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Mm
		1112933 FBW1A_MOUSE (214-451): 1.95e-39: 151: 16.87		CUL1_MOUSE (1-776): 0: 912: 100.00
+	Hs
		1041266 FBW1B_HUMAN (214-451): 3.27e-38: 147: 16.87		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1043085 WDR5B_HUMAN (180-451): 1.39e-65: 215: 20.00		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		1043441 WDR5B_HUMAN (180-451): 1.39e-65: 215: 20.00		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Hs
		1043499 FBXW7_HUMAN (30-264): 1.59e-52: 189: 19.92		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Hs
		792982 LIS1_HUMAN (21-256): 3.87e-50: 177: 16.17		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		1042655 NLE1_HUMAN (33-304): 2.54e-54: 190: 14.99		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Hs
		903208 WDR5_HUMAN (32-253): 6.76e-43: 155: 15.19		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		1043319 FBW1A_HUMAN (214-451): 3.4e-40: 153: 16.46		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		903209 WDR5_HUMAN (32-253): 6.76e-43: 155: 15.19		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Hs
		209433 PLRG1_HUMAN (178-451): 3.99e-48: 174: 19.93		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Dm
		1097201 Q9VDE3_DROME (223-451): 3.94e-39: 149: 15.39		CUL1_DROME (4-776): 0: 770: 61.98
+	Hs
		903207 WDR5_HUMAN (32-253): 6.76e-43: 155: 15.19		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Sc
		431154 CDC4_YEAST (11-417): 2.48e-75: 252: 17.41		CDC53_YEAST (13-776): 0: 629: 31.36
+	Hs
		1274084 FBW1A_HUMAN (214-451): 3.4e-40: 153: 16.46		CUL5_HUMAN (2-776): 0: 622: 28.98