HitPredict

Interactor 1: PPP6 (O00743)
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]
Gene: PPP6C

Interactor 2: TIPRL (O75663)
TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)
Gene: TIPRL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	16085932, 27880917, 36652389, 24255178, 17384681
Identification Methods	pull down, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Metallophos~TIP41
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 305 Hs			1 272
+	Hs
		272426 PP2AB_HUMAN (5-305): 0: 531: 58.80		TIPRL_HUMAN (1-272): 2.14e-147: 415: 100.00
+	Hs
		272428 PP2AA_HUMAN (5-305): 0: 531: 58.14		TIPRL_HUMAN (1-272): 2.14e-147: 415: 100.00
+	Hs
		272423 PP4C_HUMAN (5-305): 0: 527: 61.92		TIPRL_HUMAN (1-272): 2.14e-147: 415: 100.00
+	Dm
		619937 PP2A_DROME (2-305): 0: 529: 56.58		Q9W5W6_DROME (15-254): 4.22e-109: 318: 41.25
+	Sc
		618804 PP2A1_YEAST (6-305): 0: 505: 55.33		TIP41_YEAST (14-254): 5.87e-92: 277: 34.34
+	Sc
		618867 PP2A2_YEAST (6-305): 2.22e-180: 503: 55.33		TIP41_YEAST (14-254): 5.87e-92: 277: 34.34
+	Sc
		688133 PP4C_YEAST (4-305): 1.94e-138: 395: 59.28		TIP41_YEAST (14-254): 5.87e-92: 277: 34.34