HitPredict

Interactor 1: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

The method score is based on:

Property	Details
Experiments	22492994, 25036637
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 9 others more... GO:0006515 - protein quality control for misfolded or incompletely synthesized proteins GO:0019899 - enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0031647 - regulation of protein stability GO:0034605 - cellular response to heat GO:0048156 - tau protein binding GO:0051787 - misfolded protein binding GO:0051879 - Hsp90 protein binding GO:0071218 - cellular response to misfolded protein
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	1215
Hs

1	303

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024