HitPredict

Interactor 1: SPAST (Q9UBP0)
Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)
Gene: SPAST

Interactor 2: WIPI4 (Q9Y484)
WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)
Gene: WDR45

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 360
+	Hs
		913376 PRS10_HUMAN (278-605): 4.34e-113: 345: 29.64		WIPI2_HUMAN (7-357): 3.21e-89: 277: 20.77
+	Hs
		907200 PRS8_HUMAN (224-608): 1.29e-110: 339: 26.26		WIPI2_HUMAN (7-357): 3.21e-89: 277: 20.77
+	Mm
		1208128 SPAST_MOUSE (1-616): 6.34e-165: 486: 91.56		BCAS3_MOUSE (151-271): 1.31e-24: 107: 21.54
+	Hs
		1126087 FIGN_HUMAN (182-612): 5.97e-115: 362: 28.54		SNR40_HUMAN (34-350): 4.18e-58: 193: 12.65
+	Hs
		907118 PRS8_HUMAN (224-608): 1.29e-110: 339: 26.26		FBXW7_HUMAN (5-260): 5.89e-40: 151: 16.35
+	Sc
		630852 AFG2_YEAST (9-615): 7.17e-118: 370: 21.37		NLE1_YEAST (188-358): 3.76e-27: 113: 11.28
+	Sc
		636661 CDC48_YEAST (323-616): 1.67e-79: 270: 30.92		ATG18_YEAST (3-311): 1.54e-56: 193: 22.96
+	Hs
		1313646 KATL1_HUMAN (148-614): 2.34e-110: 341: 30.96		KTNB1_HUMAN (58-269): 1.58e-15: 79.8: 19.01
+	Hs
		903094 PRS10_HUMAN (278-605): 4.34e-113: 345: 29.64		WDR5_HUMAN (3-126): 1.37e-11: 66.8: 10.69
+	Hs
		903081 PRS8_HUMAN (224-608): 1.29e-110: 339: 26.26		WDR5_HUMAN (3-126): 1.37e-11: 66.8: 10.69
+	Sc
		636597 CDC48_YEAST (323-616): 1.67e-79: 270: 30.92		TAF5_YEAST (181-356): 8.33e-26: 110: 12.07
+	Hs
		875474 TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86		WIPI2_HUMAN (7-357): 3.21e-89: 277: 20.77
+	Hs
		875215 TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86		SNR40_HUMAN (34-350): 4.18e-58: 193: 12.65
+	Hs
		874768 TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86		WDR5_HUMAN (3-126): 1.37e-11: 66.8: 10.69
+	Hs
		265426 KTNA1_HUMAN (57-255): 6.43e-12: 70: 12.22		KTNB1_HUMAN (58-269): 1.58e-15: 79.8: 19.01
+	Rn
		1119112 KTNA1_RAT (57-255): 4.3e-11: 67.7: 11.77		Q4VFZ4_RAT (58-269): 1.58e-15: 79.8: 19.01
+	Mm
		1206383 KTNA1_MOUSE (57-255): 4.34e-11: 67.7: 11.77		KTNB1_MOUSE (58-269): 1.58e-15: 79.8: 19.01