HitPredict - High confidence protein-protein interactions

Interactor 1: HEY2 (Q9UBP5)
Hairy/enhancer-of-split related with YRPW motif protein 2 (Cardiovascular helix-loop-helix factor 1) (hCHF1) (Class B basic helix-loop-helix protein 32) (bHLHb32) (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (hHRT2) (Protein gridlock homolog)
Gene: HEY2

Interactor 2: HEY1 (Q9Y5J3)
Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)
Gene: HEY1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.946

Property	Details
Experiments	26186194, 28514442, 33961781, 24366871, 19802006, 27129302
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Hairy_orange~Hairy_orange, HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000987 - cis-regulatory region sequence-specific DNA binding and 31 others more... GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0003161 - cardiac conduction system development GO:0003180 - aortic valve morphogenesis GO:0003184 - pulmonary valve morphogenesis GO:0003208 - cardiac ventricle morphogenesis GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0007219 - Notch signaling pathway GO:0009952 - anterior/posterior pattern specification GO:0035912 - dorsal aorta morphogenesis GO:0036304 - umbilical cord morphogenesis GO:0045746 - negative regulation of Notch signaling pathway GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046983 - protein dimerization activity GO:0050767 - regulation of neurogenesis GO:0051151 - negative regulation of smooth muscle cell differentiation GO:0060317 - cardiac epithelial to mesenchymal transition GO:0060347 - heart trabecula formation GO:0060411 - cardiac septum morphogenesis GO:0060412 - ventricular septum morphogenesis GO:0060716 - labyrinthine layer blood vessel development GO:0060842 - arterial endothelial cell differentiation GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070168 - negative regulation of biomineral tissue development GO:0072359 - circulatory system development GO:1990837 - sequence-specific double-stranded DNA binding GO:2001212 - regulation of vasculogenesis
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	337
Hs

1	304

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Last updated: 15 Jul 2024