HitPredict

Interactor 1: FXL17 (Q9UF56)
F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13)
Gene: FBXL17

Interactor 2: KLH20 (Q9Y2M5)
Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X)
Gene: KLHL20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	26186194, 28514442, 33961781, 30190310
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTB~LRR_6
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 701 Hs			1 609
+	Hs
		1120825 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH12_HUMAN (43-600): 1.85e-164: 483: 44.31
+	Hs
		1049349 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KEAP1_HUMAN (4-608): 7.78e-159: 470: 37.30
+	Hs
		1153798 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH10_HUMAN (35-601): 7.52e-156: 462: 35.32
+	Hs
		1221252 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLHL7_HUMAN (57-581): 7.13e-96: 306: 34.39
+	Hs
		1350369 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLHL9_HUMAN (399-604): 3e-43: 166: 28.64
+	Hs
		1164601 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH17_HUMAN (448-609): 8e-34: 138: 35.19
+	Hs
		1348054 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH28_HUMAN (446-609): 4.78e-31: 129: 28.49
+	Hs
		1350481 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH13_HUMAN (462-604): 1.4e-28: 123: 26.67
+	Hs
		1354639 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH21_HUMAN (444-609): 1.96e-24: 109: 22.62
+	Hs
		1354646 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		IPP_HUMAN (508-609): 3.78e-19: 93.4: 30.00
+	Hs
		1354637 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLHL3_HUMAN (288-415): 2.34e-18: 90.7: 36.72
+	Hs
		307226 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLHL2_HUMAN (288-415): 1.35e-17: 88.4: 37.50
+	Hs
		1121505 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH26_HUMAN (441-609): 1.72e-16: 84.9: 20.79
+	Hs
		1164633 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH24_HUMAN (492-609): 2.3e-12: 71.8: 17.21
+	Hs
		1327770 FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00		KLH25_HUMAN (506-601): 5.38e-10: 64.3: 16.50