HitPredict

Interactor 1: PPP6 (O00743)
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]
Gene: PPP6C

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29509190, 25604459
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005739 - mitochondrion
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 305 Hs			1 530
+	Hs
		915249 PP2AB_HUMAN (5-305): 0: 531: 58.80		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		737951 PP1G_HUMAN (1-302): 0: 520: 40.84		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		906054 PP1A_HUMAN (4-292): 0: 517: 42.28		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369332 PP2AB_HUMAN (5-305): 0: 531: 58.80		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369364 PP2AA_HUMAN (5-305): 0: 531: 58.14		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369103 PP1G_HUMAN (1-302): 0: 520: 40.84		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369309 PP1A_HUMAN (4-292): 0: 517: 42.28		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		587097 PP1G_MOUSE (1-302): 0: 519: 40.84		ESR1_MOUSE (9-529): 4.88e-134: 403: 43.72
+	Hs
		320195 PP2AB_HUMAN (5-305): 0: 531: 58.80		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		320201 PP2AA_HUMAN (5-305): 0: 531: 58.14		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Rn
		415150 PPP6_RAT (1-305): 0: 529: 99.67		GCR_RAT (3-495): 5.89e-100: 321: 23.03
+	Hs
		487319 PP2AA_HUMAN (5-305): 0: 531: 58.14		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		437630 PP1A_HUMAN (4-292): 0: 517: 42.28		MCR_HUMAN (141-408): 5.92e-38: 150: 34.03
+	Hs
		487290 PP1A_HUMAN (4-292): 0: 517: 42.28		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59