HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.95	1.00	0.980

Method score

Annotation score

Interaction score

0.95

1.00

0.980

Property	Details
Experiments	25939384, 26915459, 28871090, 31534043, 19656901, 17599067, 23453972, 23286385, 10783893, 14560022, 14743216, 19153231, 16887178
Identification Methods	affinity chromatography technology, enzymatic study, pull down, two hybrid, x-ray crystallography, protein kinase assay, in-gel kinase assay, tandem affinity purification
Interaction Type	physical association, direct interaction, association, phosphorylation reaction

Property

Details

Experiments

25939384, 26915459, 28871090, 31534043, 19656901, 17599067, 23453972, 23286385, 10783893, 14560022, 14743216, 19153231, 16887178

Identification Methods

affinity chromatography technology, enzymatic study, pull down, two hybrid, x-ray crystallography, protein kinase assay, in-gel kinase assay, tandem affinity purification

Interaction Type

physical association, direct interaction, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase, Pkinase~TBK1_CCD1, Pkinase~TBK1_ULD, TBK1_CCD1~TBK1_CCD1, TBK1_CCD1~TBK1_ULD, TBK1_ULD~TBK1_ULD
Common GO terms	GO:0002218 - activation of innate immune response GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0003676 - nucleic acid binding GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity and 37 others more... GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0006954 - inflammatory response GO:0007249 - canonical NF-kappaB signal transduction GO:0009615 - response to virus GO:0010508 - positive regulation of autophagy GO:0010629 - negative regulation of gene expression GO:0016239 - positive regulation of macroautophagy GO:0018105 - peptidyl-serine phosphorylation GO:0018107 - peptidyl-threonine phosphorylation GO:0019903 - protein phosphatase binding GO:0032479 - regulation of type I interferon production GO:0032481 - positive regulation of type I interferon production GO:0032727 - positive regulation of interferon-alpha production GO:0032728 - positive regulation of interferon-beta production GO:0033138 - positive regulation of peptidyl-serine phosphorylation GO:0034142 - toll-like receptor 4 signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043231 - intracellular membrane-bounded organelle GO:0044565 - dendritic cell proliferation GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050830 - defense response to Gram-positive bacterium GO:0051219 - phosphoprotein binding GO:0051607 - defense response to virus GO:0060337 - type I interferon-mediated signaling pathway GO:0060340 - positive regulation of type I interferon-mediated signaling pathway GO:0106310 - protein serine kinase activity GO:0140374 - antiviral innate immune response GO:0140896 - cGAS/STING signaling pathway GO:1902554 - serine/threonine protein kinase complex GO:1904262 - negative regulation of TORC1 signaling GO:1904263 - positive regulation of TORC1 signaling GO:1904417 - positive regulation of xenophagy
Homologous interactions	16