HitPredict

Interactor 1: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Interactor 2: PTBP2 (Q9UKA9)
Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein)
Gene: PTBP2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	22365833
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~RRM_5
Common GO terms	GO:0003723 - RNA binding GO:0006376 - mRNA splice site recognition
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 559 Hs			1 531
+	Hs
		321239 PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00		PTBP3_HUMAN (1-531): 3.32e-114: 350: 65.10
+	Hs
		643504 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		PTBP1_HUMAN (1-531): 3.71e-124: 376: 66.43
+	Hs
		321076 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		PTBP3_HUMAN (1-531): 3.32e-114: 350: 65.10
+	Hs
		541188 PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00		HNRPL_HUMAN (47-529): 6.83e-62: 215: 23.00
+	Hs
		321063 ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80		PTBP3_HUMAN (1-531): 3.32e-114: 350: 65.10
+	Hs
		321161 PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86		PTBP3_HUMAN (1-531): 3.32e-114: 350: 65.10
+	Hs
		1031490 PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00		PABP4_HUMAN (47-280): 1.83e-30: 127: 12.03
+	Hs
		541010 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		HNRPL_HUMAN (47-529): 6.83e-62: 215: 23.00
+	Dm
		562816 PUF68_DROME (57-559): 1.81e-97: 311: 47.24		ELAV_DROME (316-527): 2.15e-20: 96.1: 16.46
+	Hs
		540986 ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80		HNRPL_HUMAN (47-529): 6.83e-62: 215: 23.00
+	Hs
		1031328 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		PABP4_HUMAN (47-280): 1.83e-30: 127: 12.03
+	Hs
		1020258 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		ELAV2_HUMAN (327-530): 9.38e-25: 107: 15.81
+	Hs
		1054312 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		ELAV3_HUMAN (288-529): 9.03e-24: 104: 16.90
+	Hs
		1020249 ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80		PABP4_HUMAN (47-280): 1.83e-30: 127: 12.03
+	Hs
		1119141 PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86		PAP1L_HUMAN (22-467): 4.86e-29: 123: 9.91
+	Hs
		1020306 PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86		ELAV2_HUMAN (327-530): 9.38e-25: 107: 15.81
+	Hs
		1020259 ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80		ELAV3_HUMAN (288-529): 9.03e-24: 104: 16.90
+	Hs
		1055876 PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86		ELAV3_HUMAN (288-529): 9.03e-24: 104: 16.90
+	Hs
		1020292 ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80		CELF5_HUMAN (138-262): 3.44e-11: 67.4: 12.40
+	Hs
		1132323 CELF3_HUMAN (226-309): 4.05e-19: 92.2: 26.19		CELF5_HUMAN (138-262): 3.44e-11: 67.4: 12.40