HitPredict

Interactor 1: NDKM (O00746)
Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)
Gene: NME4

Interactor 2: NDKB (P22392)
Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)
Gene: NME2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	27499296, 33961781, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	NDK~NDK
Common GO terms	GO:0004550 - nucleoside diphosphate kinase activity GO:0005524 - ATP binding GO:0006183 - GTP biosynthetic process GO:0006228 - UTP biosynthetic process GO:0006241 - CTP biosynthetic process and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 187 Hs			1 152
+	Hs
		135572 NDKM_HUMAN (1-187): 5.36e-96: 278: 100.00		NDKA_HUMAN (1-152): 1.83e-90: 261: 88.16
+	Hs
		135616 NDKM_HUMAN (1-187): 5.36e-96: 278: 100.00		NDK3_HUMAN (5-152): 1.58e-83: 244: 65.54
+	Hs
		607586 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		NDKB_HUMAN (1-152): 4.97e-92: 265: 100.00
+	Hs
		548860 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		NDKA_HUMAN (1-152): 1.83e-90: 261: 88.16
+	Hs
		548853 NDKA_HUMAN (38-185): 2.36e-85: 249: 57.43		NDKA_HUMAN (1-152): 1.83e-90: 261: 88.16
+	Hs
		135540 NDKM_HUMAN (1-187): 5.36e-96: 278: 100.00		NDKM_HUMAN (5-148): 3.05e-77: 229: 56.94
+	Hs
		607647 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		NDK3_HUMAN (5-152): 1.58e-83: 244: 65.54
+	Dm
		65459 A8E6J4_DROME (21-185): 1.46e-83: 246: 49.40		NDKA_DROME (2-152): 2.24e-86: 250: 77.48
+	Dm
		445605 NDKA_DROME (34-185): 4.3e-83: 244: 52.63		NDKA_DROME (2-152): 2.24e-86: 250: 77.48
+	Hs
		548904 NDKA_HUMAN (38-185): 2.36e-85: 249: 57.43		NDK3_HUMAN (5-152): 1.58e-83: 244: 65.54
+	Ce
		1274720 Q93576_CAEEL (34-185): 7.75e-82: 241: 51.32		Q93576_CAEEL (1-152): 3.26e-83: 242: 68.63
+	Hs
		233739 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		NDK8_HUMAN (16-152): 2.2e-77: 227: 96.35
+	At
		249500 NDK2_ARATH (4-184): 7.74e-81: 241: 44.75		NDK2_ARATH (1-152): 7.93e-80: 237: 51.32
+	Hs
		233736 NDKA_HUMAN (38-185): 2.36e-85: 249: 57.43		NDK8_HUMAN (16-152): 2.2e-77: 227: 96.35
+	Hs
		607668 NDKB_HUMAN (34-185): 4.27e-87: 254: 54.61		Q32Q12_HUMAN (1-114): 8.76e-63: 195: 90.35
+	Hs
		548912 NDKA_HUMAN (38-185): 2.36e-85: 249: 57.43		Q32Q12_HUMAN (1-114): 8.76e-63: 195: 90.35
+	Hs
		135725 NDKM_HUMAN (1-187): 5.36e-96: 278: 100.00		NDK7_HUMAN (7-135): 8.47e-39: 136: 29.32