HitPredict

Interactor 1: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33277362
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1024 Hs			1 589
+	Hs
		983269 UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		125787 WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		1336119 SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		983264 UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		125739 WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Hs
		1336106 SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		983150 UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		125225 WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02		BAG6_HUMAN (25-536): 2.14e-33: 138: 14.66
+	Sc
		477647 TOM1_YEAST (533-1024): 9.89e-156: 513: 26.70		RL40A_YEAST (37-129): 2.22e-31: 120: 28.72
+	Hs
		924414 SMUF2_HUMAN (648-1024): 5.74e-160: 491: 26.22		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Sp
		145418 PUB3_SCHPO (648-1024): 7.14e-157: 485: 26.99		RL402_SCHPO (37-126): 3.84e-31: 119: 29.67
+	Hs
		924156 WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Dm
		89880 D5SHR3_DROME (660-1024): 2.2e-152: 460: 28.57		RL40_DROME (37-126): 7.82e-34: 126: 29.67
+	Hs
		125347 WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Hs
		1065056 HERC3_HUMAN (317-460): 3.68e-11: 69.7: 10.88		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		1218013 HERC6_HUMAN (7-207): 4.36e-23: 108: 15.21		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		1065054 HERC3_HUMAN (317-460): 3.68e-11: 69.7: 10.88		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		924302 HERC3_HUMAN (317-460): 3.68e-11: 69.7: 10.88		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77