HitPredict

Interactor 1: RABX5 (Q9UJ41)
Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)
Gene: RABGEF1

Interactor 2: RABX5 (Q9UJ41)
Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)
Gene: RABGEF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.850

The method score is based on:

Property Details
Experiments 25416956, 17341663, 16499958
Identification Methods two hybrid, enzymatic study, two hybrid array, pull down
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DUF5601~VPS9, VPS9~VPS9
Common GO terms GO:0001933 - negative regulation of protein phosphorylation
GO:0002686 - negative regulation of leukocyte migration
GO:0003677 - DNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005730 - nucleolus
and 26 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 491
Hs

1 491
+ Sc
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024