HitPredict - High confidence protein-protein interactions

Interactor 1: HACL1 (Q9UJ83)
2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2)
Gene: HACL1

Interactor 2: HACL1 (Q9UJ83)
2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2)
Gene: HACL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	25416956, 16189514
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	TPP_enzyme_C~TPP_enzyme_C, TPP_enzyme_C~TPP_enzyme_M, TPP_enzyme_C~TPP_enzyme_N, TPP_enzyme_M~TPP_enzyme_M, TPP_enzyme_M~TPP_enzyme_N, TPP_enzyme_N~TPP_enzyme_N
Common GO terms	GO:0000287 - magnesium ion binding GO:0001561 - fatty acid alpha-oxidation GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005777 - peroxisome and 13 others more... GO:0005782 - peroxisomal matrix GO:0005829 - cytosol GO:0006625 - protein targeting to peroxisome GO:0006631 - fatty acid metabolic process GO:0008949 - oxalyl-CoA decarboxylase activity GO:0016830 - carbon-carbon lyase activity GO:0030976 - thiamine pyrophosphate binding GO:0033611 - oxalate catabolic process GO:0043231 - intracellular membrane-bounded organelle GO:0097089 - methyl-branched fatty acid metabolic process GO:0106359 - 2-hydroxyacyl-CoA lyase activity GO:0106376 - 2-hydroxyphytanoyl-CoA lyase activity GO:1903512 - phytanic acid metabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	578
Hs

1	578

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Last updated: 15 Jul 2024