HitPredict

Interactor 1: ANC2 (Q9UJX6)
Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)
Gene: ANAPC2

Interactor 2: FBX5 (Q9UKT4)
F-box only protein 5 (Early mitotic inhibitor 1)
Gene: FBXO5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.719

Property	Details
Experiments	34079125, 35271311, 33961781, 16921029, 23708001
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007346 - regulation of mitotic cell cycle GO:0051301 - cell division
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 447
+	Mm
		102657 ANC2_MOUSE (6-820): 0: 889: 94.85		G3X9B2_MOUSE (148-447): 3e-103: 322: 32.41
+	Hs
		1116879 ANC2_HUMAN (1-822): 0: 887: 100.00		FBX43_HUMAN (40-447): 2.63e-103: 324: 27.59
+	Hs
		1041268 CUL1_HUMAN (171-811): 5.04e-137: 426: 13.85		FBX5_HUMAN (1-447): 0: 685: 100.00
+	Hs
		1042814 CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93		FBX5_HUMAN (1-447): 0: 685: 100.00