HitPredict

Interactor 1: IKZF2 (Q9UKS7)
Zinc finger protein Helios (Ikaros family zinc finger protein 2)
Gene: IKZF2

Interactor 2: IKZF3 (Q9UKT9)
Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)
Gene: IKZF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	9560339, 35583604
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	zf-C2H2~zf-C2H2
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 509
+	Hs
		1356562 IKZF2_HUMAN (1-526): 0: 696: 100.00		IKZF2_HUMAN (4-504): 3.73e-144: 426: 46.98
+	Hs
		1033755 IKZF2_HUMAN (1-526): 0: 696: 100.00		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1332094 IKZF2_HUMAN (1-526): 0: 696: 100.00		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		1033731 IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1033630 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1329652 IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22		IKZF4_HUMAN (110-505): 5.69e-135: 404: 50.35
+	Hs
		1329658 IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		1033756 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		1356574 IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		1329653 IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		1033733 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		1332095 IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		152714 ZN197_HUMAN (2-496): 6.71e-179: 532: 14.31		ZN397_HUMAN (4-276): 7.84e-60: 207: 22.97
+	Hs
		67869 ZN724_HUMAN (8-254): 4.02e-90: 290: 23.29		ZKSC8_HUMAN (40-276): 2.8e-64: 220: 22.36
+	Hs
		485194 ZKSC7_HUMAN (14-517): 6.2e-83: 274: 20.69		ZSC22_HUMAN (141-276): 9.87e-24: 106: 19.12
+	Hs
		1109829 ZKSC7_HUMAN (14-517): 6.2e-83: 274: 20.69		ZSC23_HUMAN (66-222): 3.55e-22: 100: 33.12